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Chemokine (C motif) receptor 1
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| Identifiers | ||||||||||||||
| Symbols | XCR1; CCXCR1; GPR5 | |||||||||||||
| External IDs | OMIM: 600552 MGI: 1346338 HomoloGene: 21095 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 2829 | 23832 | ||||||||||||
| Ensembl | ENSG00000173578 | ENSMUSG00000060509 | ||||||||||||
| Uniprot | P46094 | Q544D8 | ||||||||||||
| Refseq | NM_001024644 (mRNA) NP_001019815 (protein) |
NM_011798 (mRNA) NP_035928 (protein) |
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| Location | Chr 3: 46.04 - 46.04 Mb | Chr 9: 123.7 - 123.71 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).
XCR1 is also known as GPR5.
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]
References
Further reading
- Maghazachi AA (1999). "Intracellular signalling pathways induced by chemokines in natural killer cells.". Cell. Signal. 11 (6): 385–90. PMID 10400311.
- Gao JL, Kuhns DB, Tiffany HL, et al. (1993). "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.". J. Exp. Med. 177 (5): 1421–7. PMID 7683036.
- Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors.". DNA Cell Biol. 14 (1): 25–35. PMID 7832990.
- Yoshida T, Imai T, Kakizaki M, et al. (1998). "Identification of single C motif-1/lymphotactin receptor XCR1.". J. Biol. Chem. 273 (26): 16551–4. PMID 9632725.
- Shan L, Qiao X, Oldham E, et al. (2000). "Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1.". Biochem. Biophys. Res. Commun. 268 (3): 938–41. doi:. PMID 10679309.
- Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.". Cytogenet. Cell Genet. 87 (3-4): 265–8. PMID 10702689.
- Kurt RA, Bauck M, Harma S, et al. (2001). "Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo.". Cell. Immunol. 209 (2): 83–8. doi:. PMID 11446740.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Shinkai H, Morozumi T, Toki D, et al. (2005). "Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1.". Gene 349: 55–66. doi:. PMID 15777643.
- Lüttichau HR, Johnsen AH, Jurlander J, et al. (2007). "Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3.". J. Biol. Chem. 282 (24): 17794–805. doi:. PMID 17403668.
External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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