Whiting reaction
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The Whiting reaction is an organic reaction converting a propargyl diol into a diene using lithium aluminium hydride.1

Whiting reaction

This organic reduction has been applied in the synthesis of facapentadiene.234

Whiting reaction application

References

  1. ^ Nayler, P.; Whiting, M. C. J. Chem. Soc. 1954, 4006-4009.
  2. ^ Synthesis of crystalline (.+-.)-fecapentaene Hans Rudolf Pfaendler, Franz Karl Maier, and Sonja Klar J. Am. Chem. Soc.; 1986; 108(6) pp 1338 - 1339. (doi:10.1021/ja00266a057)
  3. ^ a mutagenic glyceryl ether lipid which can occur in trace amounts in the feces of people living in industrialized countries and are suspected to be a cause for colon cancer
  4. ^ protecting groups are tetrahydropyranyl and TBSMS, the final step is deprotection with tetra-n-butylammonium fluoride
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