The Whitechapel tube station is on the north side of the road. Behind the tube station is the former site of Blackwall Buildings notable philathropic housing built in 1890 and demolished in 1969. Opposite to the south is the Royal London Hospital. St Mary's tube station used to be on Whitechapel Road, but closed in 1938. It was used as an air raid shelter in World War II, but was destroyed by bombing in 1940.
The well-known Whitechapel Bell Foundry is based in buildings on Whitechapel Road that date from 1670. They were formerly used as a coaching inn known as The Artichoke. The buildings replaced smaller premises on the north side of the road.