Vitamin-K-epoxide reductase (warfarin-insensitive)
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Vitamin-K-epoxide_reductase_(warfarin-insensitive)".

In enzymology, a vitamin-K-epoxide reductase (warfarin-insensitive) (EC 1.1.4.2) is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol

Thus, the two substrates of this enzyme are 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone and oxidized dithiothreitol, whereas its two products are 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone and 1,4-dithiothreitol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a disulfide as acceptor. The systematic name of this enzyme class is 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithi othreitol oxidoreductase.

References

• IUBMB entry for 1.1.4.2
• BRENDA references for 1.1.4.2 (Recommended.)
• PubMed references for 1.1.4.2
• PubMed Central references for 1.1.4.2
• Google Scholar references for 1.1.4.2
• Mukharji I, Silverman RB (1985). "Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone". Proc. Natl. Acad. Sci. U. S. A. 82: 2713–7. PMID 3857611. 

External links

The CAS registry number for this enzyme class is 97089-80-0.

• IUBMB entry for 1.1.4.2

• KEGG entry for 1.1.4.2

• BRENDA entry for 1.1.4.2

• NiceZyme view of 1.1.4.2

• EC2PDB: PDB structures for 1.1.4.2

• PRIAM entry for 1.1.4.2

• PUMA2 entry for 1.1.4.2

• IntEnz: Integrated Enzyme entry for 1.1.4.2

• MetaCyc entry for 1.1.4.2

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047058: vitamin-K-epoxide reductase (warfarin-insensitive)

• AMIGO entry for GO code 0047058: vitamin-K-epoxide reductase (warfarin-insensitive)

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