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Manufacture
Manufacturers of Vicodin (generic or otherwise) include Abbott Laboratories (makers of trademark Vicodin), Amerisource Health Services Corp, Cardinal Health, Drx Pharmaceutical Consultants Inc, Eckerd Corp, Hospira Inc, Knoll Laboratories Div Knoll Pharmaceutical Co, Mallinckrodt Pharm. Quality Care, Pdrx Pharmaceuticals Inc, Physicians Total Care Inc, Rx Pak Div of Mckesson Corp, Sandhills Packaging Inc, and Watson Pharmaceuticals. Generic Vicodin by some of the aforementioned manufacturers is often substituted by pharmacies for prescriptions for trademark Vicodin from Abbott Labs. Aggregated, Vicodin production reportedly approaches twenty tons annually.citation needed
Ingredients
- Vicodin contains 500mg acetaminophen and 5mg hydrocodone
- Vicodin ES contains 750mg acetaminophen and 7.5mg hydrocodone
- Vicodin HP contains 660mg acetaminophen and 10mg hydrocodone
The theory of adding acetaminophen is a reduction in abuse potential; multiple doses will result in nauseous symptoms and stomach complications. It should be noted that hydrocodone is soluble in water even at low temperatures.
Regulation and scheduling
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In the United States, Vicodin production is regulated in part by the Controlled Substances Act of 1970. This guarantees that all manufacturing, importing, possession, and distribution of drugs is to be overseen and regulated by the federal government, which is also responsible (along with the Department of Justice and state governments) for the conviction and sentencing of anyone who breaks drug laws.[2]
In the U.S., Vicodin is on the Schedule III list of drugs. Other drugs on this list include anabolic steroids, dihydrocodeine, dronabinol, ergine, ketamine, paregoric, and Xyrem; codeine and hydrocodone are also Schedule III but only when compounded with paracetamol or with an NSAID. Schedule III drugs are classified by the U.S. government as potentially causing moderate or low physical dependence or a high psychological dependence if abused. There is a high inclination for abuse of this drug.
Indications
Vicodin, like other opioid analgesics, is used to manage pain. It is most commonly prescribed for relief of mild to moderate pain of acute, chronic, or post-operative types. Vicodin belongs to the opiate family of drugs.
Side effects
Side effects for Vicodin include an allergic reaction, seizures, clammy skin, severe weakness, dizziness, hyperventilation, unconsciousness, jaundice (yellowing of eyes or skin), unusual fatigue, bleeding, bruising, stomach pain,[3] constipation, dry mouth, nausea, vomiting, decreased appetite, muscle twitches, sweating, hot flashes, itching, tinnitus, hearing loss, decreased urination, and decreased sex drive.[4] Vicodin (in terms of hydrocodone) also has depressant effects on the central nervous system.[5] However, some of the less mundane effects can be desirable effects that are sought after by some. Those effects include euphoria and drowsiness, as well as slowing of the pulse.[6] Vicodin may also be a cause of stomach ulcers, although this is assumed to be due to the addition of other non-narcotic analgesics to hydrocodone preparations (e.g., aspirin, and ibuprofen). Paracetamol does not cause ulcers, unlike NSAIDS, but has a severe liver toxicity as of 8g per day or even 4g with renal insufficiency.
References
- ^ http://endoflife.stanford.edu/M11_pain_control/doses_m01.html Pain Control: Opioid Conversion
- ^ [1]dead link
- ^ Anonymous (March 24, 2008). "Vicodin". Cerner Multum, Inc.. Retrieved on 2008-06-09.
- ^ Vicodin's Effects and Dangers
- ^ 21 CFR - Section 13001.01 Definitions relating to controlled substances
- ^ Vicodin Side Effects, Vicodin Detox
External links
