| County |
Location |
Mile1 |
Destinations |
Notes |
| Lake |
New Pine Creek |
157.73 |
California state line |
| Lakeview |
143.03 |
OR 140 west – Bly, Klamath Falls |
South end of OR 140 overlap |
|
138.34 |
OR 140 east – Adel, Plush, Winnemucca |
North end of OR 140 overlap |
| Valley Falls |
120.57
90.02 |
OR 31 – Paisley, Silver Lake, Bend |
|
| Harney |
Riley |
0.11
104.77 |
US 20 west – Bend, Redmond, Portland |
South end of US 20 overlap |
| Burns |
131.50 |
OR 78 – Crane, Winnemucca |
|
|
134.29
67.61 |
US 20 east – Vale, Ontario |
North end of US 20 overlap |
| Grant |
Canyon City |
0.00
162.29 |
US 26 east – Prairie City, Vale, Baker City |
South end of US 26 overlap |
| Mount Vernon |
154.03
120.51 |
US 26 west – Dayville, Prineville, Portland |
North end of US 26 overlap |
| Long Creek |
90.26 |
OR 402 – Hamilton, Monument, Kimberly |
|
| Umatilla |
|
49.57 |
OR 244 east – Ukiah, La Grande |
|
| Nye |
23.65 |
OR 74 west – Heppner, Condon |
|
| Pendleton |
1.57
209.17 |
 I-84 east / OR 37 north , Pendleton City Center |
Interchange; south end of I-84 overlap; south end of freeway |
| 207.47 |
US 30 east – Eastern Oregon Regional Airport, West Pendleton, Pendleton City Center |
South end of US 30 overlap |
|
202.87 |
Barnhart Road – Stage Gulch |
|
|
199.53 |
Yoakum Road – Stage Gulch |
|
|
198.54 |
Lorenzen Road, McClintock Road |
|
|
193.53 |
Echo Road – Echo, Lexington |
Former Lexington-Echo Highway |
| Stanfield |
188.98
12.68 |
 I-84 west / US 30 west (Lexington-Echo Highway) – Boardman, Echo |
Interchange; north end of I-84 / US 30 overlap; north end of freeway |
| Hermiston |
4.83 |
OR 207 – Heppner, Walla Walla |
|
| Umatilla |
0.04
184.87 |
US 730 east – Walla Walla, McNary Dam |
South end of US 730 overlap |
184.40
0.79 |
  I-82 east to I-84 / US 730 west – Pendleton, Portland, Umatilla, Irrigon |
Interchange; north end of US 730 overlap; south end of I-82 overlap |
| 0.00 |
Umatilla Bridge over the Columbia River (state line) |