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Anatomy
The somatosensory system is spread through all major parts of a mammal's body (and other vertebrates). It consists both of sensory receptors and sensory (afferent) neurones in the periphery (skin, muscle and organs for example), to deeper neurones within the central nervous system.
General somatosensory pathway
A somatosensory pathway typically has three long neurons[1]: primary, secondary and tertiary (or first, second, and third).
- The first neuron always has its cell body in the dorsal root ganglion of the spinal nerve (if sensation is in head or neck, it will be the trigeminal nerve ganglia or the ganglia of other sensory cranial nerves).
- The second neuron has its cell body either in the spinal cord or in the brainstem. This neurones ascending axons will cross (decussate) to the opposite side either in the spinal cord or in the brainstem. The axons of many of these neurones terminate in the thalamus (for example the ventral posterior nucleus, VPN), others terminate in the reticular system or the cerebellum.
- In the case of touch and certain types of pain, the third neuron has its cell body in the VPN of the thalamus and ends in the postcentral gyrus of the parietal lobe.
Periphery
In the periphery, the somatosensory system detects various stimuli by sensory receptors, e.g. by mechanoreceptors. The sensory information (touch, pain, temperature etc.,) is then conveyed to the central nervous system by afferent neurones. There are a number of different types of afferent neurones which vary in their size, structure and properties. Generally there is a correlation between the type of sensory modality detected and the type of afferent neurone involved. So for example slow, thin unmyelinated neurones conduct casual touch whereas faster, thicker, myelinated neurones conduct pain.
Spinal cord
In the spinal cord, the somatosensory system [2] includes ascending pathways from the body to the brain. One major target within the brain is the postcentral gyrus in the cerebral cortex. This is the target for neurones of the Dorsal Column Medial Lemniscal pathway and the Ventral Spinothalamic pathway. Note that many ascending somatosensory pathways include synapses in either the thalamus or the reticular formation before they reach the cortex. Other ascending pathways, particularly those involved with control of posture are projected to the cerebellum. These include the ventral and dorsal spinocerebellar tracts. Another important target for afferent somatosensory neurones which enter the spinal cord are those neurones involved with local segmental reflexes.
Brain
The primary somatosensory area in the human cortex is located in the postcentral gyrus of the parietal lobe. The postcentral gyrus is the location of the primary somatosensory area, the main sensory receptive area for the sense of touch. Like other sensory areas, there is a map of sensory space called a homunculus at this location. For the primary somatosensory cortex, this is called the sensory homunculus. Areas of this part of the human brain map to certain areas of the body, dependent on the amount or importance of somatosensory input from that area. For example, there is a large area of cortex devoted to sensation in the hands, while the back has a much smaller area. Interestingly, one study showed somatosensory cortex was found to be 21% thicker in 24 migraine sufferers, on average than in 12 controls[3], although we do not yet know what the significance of this is. Somatosensory information involved with proprioception and posture also targets an entirely different part of the brain, the cerebellum.
Physiology
Initiation of probably all "somatosensation" begins with activation of some sort of physical "receptor". These somatosensory receptors tend to lie in skin, organs or muscle. The structure of these receptors is broadly similar in all cases, consisting of either a "free nerve ending" or a nerve ending embedded in a specialised capsule. They can be activated by movement (mechanoreceptor), pressure (mechanoreceptor), chemical (chemoreceptor) and/or temperature. In each case, the general principle of activation is similar; the stimulus causes depolarisation of the nerve ending and then an action potential is initiated. This action potential then (usually) travels inward towards the spinal cord.
Technology
The new research area of haptic technology can provide touch sensation in virtual and real environments. This new discipline has started to provide critical insights into touch capabilities.
See also
Notes
- ^ Saladin KS. Anatomy and Physiology 3rd ed. 2004. McGraw-Hill, New York.
- ^ Nolte J.The Human Brain 5th ed. 2002. Mosby Inc, Missouri.
- ^ "Thickening in the somatosensory cortex of patients with migraine." Alexandre F.M. DaSilva, Cristina Granziera, Josh Snyder, and Nouchine Hadjikhani. Neurology, Nov 2007; 69: 1990 - 1995.
References
- Emile L. Boulpaep; Walter F. Boron (2003). Medical Physiology. Saunders, 352-358. ISBN 0-7216-3256-4.
- Flanagan, J.R., Lederman, S.J. Neurobiology: Feeling bumps and holes, News and Views, Nature, 2001 Jul. 26;412(6845):389-91.
- Hayward V, Astley OR, Cruz-Hernandez M, Grant D, Robles-De-La-Torre G. Haptic interfaces and devices. Sensor Review 24(1), pp. 16-29 (2004).
- Robles-De-La-Torre G., Hayward V. Force Can Overcome Object Geometry In the perception of Shape Through Active Touch. Nature 412 (6845):445-8 (2001).
- Robles-De-La-Torre G. The Importance of the Sense of Touch in Virtual and Real Environments. IEEE Multimedia 13(3), Special issue on Haptic User Interfaces for Multimedia Systems, pp. 24-30 (2006).
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