His work in South Africa inspired the novelsRiotous Assembly and Indecent Exposure. From 1963 until 1972 he was a History lecturer at the Cambridge College of Arts and Technology, which inspired his "Wilt" series Wilt, The Wilt Alternative, Wilt on High and Wilt in Nowhere.
His novels feature bitter and outrageous satire of the apartheid regime (Riotous Assembly and its sequel Indecent Exposure), "dumbed-" or watered-down education (the Wilt series), English class snobbery (Ancestral Vices, Porterhouse Blue, Grantchester Grind), the literary world (The Great Pursuit), political extremists of all stripes, political correctness, bureaucracy and stupidity in general. Characters may indulge in bizarre sexual practices, and coarser characters use very graphic and/or profane language in dialogue. Sharpe often parodies the language and style of specific authors commonly associated with the social group held up for ridicule. Sharpe's bestselling books have been translated into many languages.