Threonine aldolase
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Threonine_aldolase".

In enzymology, a threonine aldolase (EC 4.1.2.5) is an enzyme that catalyzes the chemical reaction

L-threonine glycine + acetaldehyde

Hence, this enzyme has one substrate, L-threonine, and two products, glycine and acetaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-threonine acetaldehyde-lyase (glycine-forming). This enzyme is also called L-threonine acetaldehyde-lyase. This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1JG8, 1LW4, 1LW5, 1M6S, and 1SVV.

References

• IUBMB entry for 4.1.2.5
• BRENDA references for 4.1.2.5 (Recommended.)
• PubMed references for 4.1.2.5
• PubMed Central references for 4.1.2.5
• Google Scholar references for 4.1.2.5
• Bell SC and Turner JM (1973). "Bacterial threonine aldolase and serine hydroxymethyltransferase enzyme". Biochem. Soc. Trans. 1: 678–681. 
• KARASEK MA, GREENBERG DM (1957). "Studies on the properties of threonine aldolases". J. Biol. Chem. 227: 191–205. PMID 13449064. 
• Kumagai H, Nagate T, Yoshida H, Yamada H (1972). "Threonine aldolase from Candida humicola. II. Purification, crystallization and properties". Biochim. Biophys. Acta. 258: 779–90. PMID 5017702. 

External links

The CAS registry number for this enzyme class is 62213-23-4.

• IUBMB entry for 4.1.2.5

• KEGG entry for 4.1.2.5

• BRENDA entry for 4.1.2.5

• NiceZyme view of 4.1.2.5

• EC2PDB: PDB structures for 4.1.2.5

• PRIAM entry for 4.1.2.5

• PUMA2 entry for 4.1.2.5

• IntEnz: Integrated Enzyme entry for 4.1.2.5

• MetaCyc entry for 4.1.2.5

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0004793: threonine aldolase

• AMIGO entry for GO code 0004793: threonine aldolase

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