The strip was about a boy called Will who had three germs inside him (Ugly Jack Bacteria, Jeremy Germ and Iris the Virus), and they were constantly making Will ill, requiring many visits to the doctor. Iris' name later changed to Violet Virus.
The strip was originally drawn by David Sutherland, and was taken over by Vic Neill later on. Around this time Will's name was added onto the title, the wording changing every so often, such as (also featuring Ill Will), (also starring Ill Will) or (with Ill Will). After Neill died in 2000, the strip disappeared from The Beano, but in 2004 it briefly returned with a new artist, Nigel Parkinson.
