Serine C-palmitoyltransferase
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Serine_C-palmitoyltransferase".

In enzymology, a serine C-palmitoyltransferase (EC 2.3.1.50) is an enzyme that catalyzes the chemical reaction

palmitoyl-CoA + L-serine CoA + 3-dehydro-D-sphinganine + CO₂

Thus, the two substrates of this enzyme are palmitoyl-CoA and L-serine, whereas its 3 products are CoA, 3-dehydro-D-sphinganine, and CO₂.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating). Other names in common use include serine palmitoyltransferase, SPT, 3-oxosphinganine synthetase, and acyl-CoA:serine C-2 acyltransferase decarboxylating. This enzyme participates in sphingolipid metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2JG2 and 2JGT.

References

• IUBMB entry for 2.3.1.50
• BRENDA references for 2.3.1.50 (Recommended.)
• PubMed references for 2.3.1.50
• PubMed Central references for 2.3.1.50
• Google Scholar references for 2.3.1.50
• Brady RN, Di Mari SJ, Snell EE (1969). "Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri". J. Biol. Chem. 244: 491–6. PMID 4388074. 
• Stoffel W, LeKim D, Sticht G (1968). "Biosynthesis of dihydrosphingosine in vitro". Hoppe. Seylers. Z. Physiol. Chem. 349: 664–70. PMID 4386961. 

External links

The CAS registry number for this enzyme class is 62213-50-7.

• IUBMB entry for 2.3.1.50

• KEGG entry for 2.3.1.50

• BRENDA entry for 2.3.1.50

• NiceZyme view of 2.3.1.50

• EC2PDB: PDB structures for 2.3.1.50

• PRIAM entry for 2.3.1.50

• PUMA2 entry for 2.3.1.50

• IntEnz: Integrated Enzyme entry for 2.3.1.50

• MetaCyc entry for 2.3.1.50

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0004758: serine C-palmitoyltransferase

• AMIGO entry for GO code 0004758: serine C-palmitoyltransferase

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