Seminoma
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Seminoma Classification and external resources
ICD-10	C62.
ICD-9	186
ICD-O:	9061
OMIM	273300
DiseasesDB	12966
eMedicine	med/2250
MeSH	D018239

Seminoma is one type of testicular cancer¹ that is believed to originate from the germinal epithelium of the seminiferous tubules.

Presentation

They produce bulky masses that can be up to ten times the size of a normal testis.

Diagnosis

POU2AF1 and PROM1 have been proposed as possible markers.²

Peak incidence occurs in the 4th decade of life. Histology shows large cells, clear cytoplasm, distinct cell membranes, and septated arcitecture.

Treatment

In recent years, these tumors have been shown to have dramatic sensitivity to both radiotherapy and cytotoxic chemotherapy. The management of childhood seminoma is similar to that of adult seminoma. Orchidectomy is required in almost all cases.

Relation to spermatocytic seminoma

Spermatocytic seminomas are not considered a subtype of seminoma and unlike other germ cell tumours do not arise from intratubular germ cell neoplasia.³

Additional images

Histopathological image of metastatic seminoma in the inguinal lymph node. Hematoxylin & eosin stain.

Histopathological image of metastatic seminoma in the inguinal lymph node. At higher magnification. Hematoxylin & eosin stain.

References

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