He was compelled by financial necessities, created in part by the heavy war-indemnity exacted by Rome, to pursue an ambitious policy. In an effort to collect money to pay the Romans, he sent his minister Heliodorus to Jerusalem to seize the temple treasury. This is mentioned in Daniel 11:20, "He will send out a tax collector to maintain the royal splendor". On his return, Heliodorus assassinated Seleucus, and seized the throne for himself.
The true heir Demetrius, son of Seleucus, now being retained in Rome as a hostage, the kingdom was seized by the younger brother of Seleucus, Antiochus IV Epiphanes, who managed to oust Heliodorus, even though an infant son, also named Antiochus, was formal head of state for a few years until Epiphanes had him murdered.
