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| Selamectin | |
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| Identifiers | |
| CAS number | 165108-07-6 |
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| Properties | |
| Molecular formula | C43H63NO11 |
| Molar mass | 769.96 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Selamectin is the active ingredient in the prescription drug Revolution (manufactured by Pfizer Canada .1), a topical insecticide and antihelminthic used on dogs and cats. It controls outbreaks of fleas, heartworm, hookworms, roundworms, and ear mites. Selamectin is not approved for human use.
How it works
Selamectin disables parasites by replacing glutamate in their muscle synapses; glutamate is the amino acid which normally interacts with the receptors that open chloride channels into the muscle. Selamectin interferes with this process; it activates the chloride current without desensitization, allowing chloride ions to enter the nerve cells and causing neuromuscular paralysis, impaired muscular contraction, and eventual death.
Selamectin fights both internal and surface parasitic infection. Absorbed into the body through the skin and hair follicles, it travels through the bloodstream, intestines, and sebaceous glands; parasites ingest the drug when they feed on the animal's blood.
A 2003 report by E. Pipano in the Israel Journal of Veterinary Medicine describes the testing of Selamectin for safety and effectiveness, and the positive results 2.
References
- ^ "Label for Revolution (selamectin topical solution) Topical Parasiticide for Dogs and Cats". Pfizer Canada Inc.. Retrieved on 2008-07-05.
- ^ Pipano, E. (2003). "RECENT DEVELOPMENTS IN THE CONTROL OF ECTOPARASITES AND ENDOPARASITES OF DOGS AND CATS WITH SELAMECTIN". Israel Journal of Veterianry Medicine 58 (2-3), http://www.isrvma.org/article/58_2_1.htm. Retrieved on 5 July 2008.
External links
