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Solute carrier family 6 (neurotransmitter transporter, GABA), member 1
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| Identifiers | ||||||||||||||
| Symbols | SLC6A1; GABATHG; GABATR; GAT1 | |||||||||||||
| External IDs | OMIM: 137165 MGI: 95627 HomoloGene: 2290 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 6529 | 232333 | ||||||||||||
| Ensembl | ENSG00000157103 | ENSMUSG00000030310 | ||||||||||||
| Uniprot | P30531 | Q6PCX2 | ||||||||||||
| Refseq | NM_003042 (mRNA) NP_003033 (protein) |
XM_975926 (mRNA) XP_981020 (protein) |
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| Location | Chr 3: 11.01 - 11.06 Mb | Chr 6: 114.25 - 114.28 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Solute carrier family 6 (neurotransmitter transporter, GABA), member 1, also known as SLC6A1, is a human gene.[1]
See also
References
Further reading
- Nelson H, Mandiyan S, Nelson N (1990). "Cloning of the human brain GABA transporter.". FEBS Lett. 269 (1): 181–4. PMID 2387399.
- Huang F, Shi LJ, Heng HH, et al. (1996). "Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25.". Genomics 29 (1): 302–4. doi:. PMID 8530094.
- Bennett ER, Kanner BI (1997). "The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain.". J. Biol. Chem. 272 (2): 1203–10. PMID 8995422.
- Bismuth Y, Kavanaugh MP, Kanner BI (1997). "Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition.". J. Biol. Chem. 272 (26): 16096–102. PMID 9195904.
- DeFelipe J, González-Albo MC (1998). "Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex.". Neuroreport 9 (3): 467–70. PMID 9512391.
- Conti F, Melone M, De Biasi S, et al. (1998). "Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex.". J. Comp. Neurol. 396 (1): 51–63. PMID 9623887.
- Beckman ML, Bernstein EM, Quick MW (1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.". J. Neurosci. 18 (16): 6103–12. PMID 9698305.
- Augood SJ, Waldvogel HJ, Münkle MC, et al. (1999). "Localization of calcium-binding proteins and GABA transporter (GAT-1) messenger RNA in the human subthalamic nucleus.". Neuroscience 88 (2): 521–34. PMID 10197772.
- Ong WY, Yeo TT, Balcar VJ, Garey LJ (2000). "A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey.". J. Neurocytol. 27 (10): 719–30. PMID 10640187.
- Deken SL, Beckman ML, Boos L, Quick MW (2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A.". Nat. Neurosci. 3 (10): 998–1003. doi:. PMID 11017172.
- Whitworth TL, Quick MW (2001). "Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.". J. Biol. Chem. 276 (46): 42932–7. doi:. PMID 11555659.
- Hachiya Y, Takashima S (2002). "Development of GABAergic neurons and their transporter in human temporal cortex.". Pediatr. Neurol. 25 (5): 390–6. PMID 11744314.
- Quick MW (2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner.". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91. doi:. PMID 11960023.
- Kanner BI (2003). "Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes.". J. Biol. Chem. 278 (6): 3705–12. doi:. PMID 12446715.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Zomot E, Kanner BI (2003). "The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV.". J. Biol. Chem. 278 (44): 42950–8. doi:. PMID 12925537.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
- Zhou Y, Bennett ER, Kanner BI (2004). "The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands.". J. Biol. Chem. 279 (14): 13800–8. doi:. PMID 14744863.
- Hu JH, Ma YH, Jiang J, et al. (2004). "Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1).". Neuroreport 15 (1): 9–12. PMID 15106822.
- Korkhov VM, Farhan H, Freissmuth M, Sitte HH (2005). "Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II.". J. Biol. Chem. 279 (53): 55728-36. doi:. PMID 15496410.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
