Cranworth was not reappointed when Palmerston returned to office in 1859, but on the retirement of Lord Westbury in 1865 he accepted the office for a second time, and held it till the fall of the Russell administration in 1866. Cranworth died in London on 26 July1868. He was childless and the title became extinct on his death.
9 days before his death, he gave judgment in the case of Rylands v Fletcher, one of the most famous cases in English legal history.