Ribose-phosphate diphosphokinase

content

phosphoribosyl pyrophosphate synthetase 1
Identifiers
Symbol	PRPS1
Entrez	5631
HUGO	9462
OMIM	311850
RefSeq	NM_002764
UniProt	P60891
Other data
EC number	2.4.2.17
Locus	Chr. X q21-q27

phosphoribosyl pyrophosphate synthetase 2
Identifiers
Symbol	PRPS2
Entrez	5634
HUGO	9465
OMIM	311860
RefSeq	NM_002765
UniProt	P11908
Other data
EC number	2.4.2.17
Locus	Chr. X pter-q21

Ribose-phosphate diphosphokinase (or phosphoribosyl pyrophosphate synthetase) is an enzyme which converts ribose 5-phosphate into phosphoribosyl pyrophosphate.

It is classified under EC 2.7.6.1.

External links

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v • d • e Transferases: Phosphotransferases/kinases (EC 2.7)

2.7.1 - OH acceptor	Hexo- - Gluco- - Fructo- (Hepatic fructo-) - Galacto- - Phosphofructo- (1, 2) - Riboflavin - Shikimate - Thymidine - NAD⁺ - Glycerol - Pantothenate - Mevalonate - Pyruvate - Deoxycytidine - PFP - Diacylglycerol - Bruton's tyrosine - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Sphingosine

2.7.2 - COOH acceptor	Phosphoglycerate - Aspartate

2.7.3 - N acceptor	Creatine

2.7.4 - PO₄ acceptor	Phosphomevalonate - Adenylate - Nucleoside-diphosphate

2.7.6 - P₂O₇	Ribose-phosphate diphosphokinase - Thiamine pyrophosphokinase

2.7.7 - nucleotidyl-	Integrase - PNPase - Polymerase - RNase PH - UDP-glucose pyrophosphorylase - Galactose-1-phosphate uridylyltransferase -Terminal deoxynucleotidyl transferase - RNA replicase - Reverse transcriptase (Telomerase) - Transposase

2.7.8 - other phos.	N-acetylglucosamine-1-phosphate transferase

2.7.10-11 - protein	Tyrosine - Serine/threonine-specific

v • d • e

Anabolism	R5P->IMP: Ribose-phosphate diphosphokinase - Amidophosphoribosyltransferase - Phosphoribosylglycinamide formyltransferase - AIR synthetase (FGAM cyclase) - Phosphoribosylaminoimidazole carboxylase - Phosphoribosylaminoimidazolesuccinocarboxamide synthase - IMP synthase IMP->AMP: Adenylosuccinate synthase - Adenylosuccinate lyase - reverse (AMP deaminase) IMP->GMP: IMP dehydrogenase - GMP synthase - reverse (GMP reductase)

Nucleotide salvage	Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase

Catabolism	Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase

Anabolism	CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase CTP synthase

Catabolism	Dihydropyrimidine dehydrogenase - Dihydropyrimidinase/DPYS - Beta-ureidopropionase/UPB1

see also disorders, intermediates