The pre-integration complex is generally composed of the viral genetic material and associated proteins (viral and host) after release into the cell. In HIV, this includes the viral core which surrounds the RNA. This complex is responsible for reverse transcription of the viral RNA genome into dsDNA and prepares it for retroviral integration into the host DNA within the nucleus.[1]
^ Smith, Johanna A.; Nunnari, Giuseppe; Preuss, Mirjam ; Pomerantz, Roger J.; Daniel, René (Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia) (2007). "Pentoxifylline Suppresses Transduction by HIV-1-Based Vectors". Intervirology50 (5): 377-386. doi:10.1159/000109752.
