Beginning in 1985, Renu Khator began a twenty-two year career affiliation with the University of South Florida (USF). Khator served in various positions at USF, culminating in her position as provost and senior vice-president of the university.
On 15 October2007, the University of Houston announced Khator as the sole-finalist for the vacant position of president at the university and chancellor of the affiliated system. On 5 November2007, she was confirmed by the board of regents for the dual-position.[4] Khator officially took her position in January of 2008.