Proflavine (pron. pro-flaÂĒvin), also called proflavin and diaminoacridine, is an acriflavine derivative, a disinfectantbacteriostatic against many gram-positivebacteria. It has been used in the form of the dihydrochloride and hemisulfate salts as a topicalantiseptic, and was formerly used as a urinary antiseptic.
Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acidbase pairs. It differs from most other mutagenic components by causing basepair-deletions or basepair-insertions and not substitutions.
Proflavine absorbs strongly in the blue region at 445nm (in water at PH7) with molar extinction coefficient of c. 40,000 [1]
