According to the Liber Pontificalis, he was Greek by birth; however this is uncertain and disputed[1] by modern western historians arguing that the authors of Liber Pontificalis confused him with that of the contemporary author Xystus who was Greek student of Pythagoreanism. He restored the relations with the African and Eastern churches which had been broken off by his predecessor on the question of hereticalbaptism.
In the persecutions under Emperor Valerian I in 258, numerous priests and bishops were put to death. Pope Sixtus II was one of the first victims of this persecution, being beheaded on August 6. He was martyred along with six deacons—Januarius, Vincentius, Magnus, Stephanus, Felicissimus and Agapitus[1].
He is thought to be the author of the pseudo-Cyprianic writing Ad Novatianum, though this view has not found general acceptance. Another composition written at Rome, between 253 and 258, is generally agreed to be his.
The following inscription honoring was placed on his tomb by Pope Saint Damasus I:
At the time when the sword pierced the bowels of the Mother, I, buried here, taught as Pastor the Word of God; when suddenly the soldiers rushed in and dragged me from the chair. The faithful offered their necks to the sword, but as soon as the Pastor saw the ones who wished to rob him of the palm (of martyrdom) he was the first to offer himself and his own head, not tolerating that the (pagan) frenzy should harm the others. Christ, who gives recompense, made manifest the Pastor's merit, preserving unharmed the flock.citation needed