Phosphoribosylaminoimidazole carboxylase

Phosphoribosylaminoimidazole carboxylase
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phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Identifiers
Symbol	PAICS
Alt. Symbols	PAIS
Entrez	10606
HUGO	8587
OMIM	172439
RefSeq	NM_006452
UniProt	P22234
Other data
EC number	4.1.1.21
Locus	Chr. 4 pter-q21

Phosphoribosylaminoimidazole carboxylase (or AIR carboxylase) is an enzyme involved in nucleotide synthesis.

It catalyzes the conversion of 5'-phosphoribosyl-5-aminoimidazole ("AIR") into 5-phosphoribosyl-4-carboxy-5-aminoimidazole ("CAIR").

External links

MeSH phosphoribosylaminoimidazole+carboxylase

This biochemistry article is a stub. You can help Wikipedia by expanding it.

v • d • e Carbon-carbon lyases (EC 4.1)

4.1.1: Carboxy-lyases	Pyruvate decarboxylase -Oxaloacetate decarboxylase - Acetoacetate decarboxylase - Malonyl-CoA decarboxylase - Glutamate decarboxylase - Ornithine decarboxylase - Lysine decarboxylase - Phosphoribosylaminoimidazole carboxylase - Histidine decarboxylase - Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase - Aromatic L-amino acid decarboxylase - Phosphoenolpyruvate carboxylase - Pyrophosphomevalonate decarboxylase - Uroporphyrinogen III decarboxylase - RuBisCO - Phosphoenolpyruvate carboxykinase - Adenosylmethionine decarboxylase

4.1.2: Aldehyde-lyases	Aldolase A/Aldolase B - 2-hydroxyphytanoyl-CoA lyase - Threonine aldolase

4.1.3: Oxo-acid-lyases	3-hydroxy-3-methylglutaryl-CoA lyase

v • d • e

Metabolism: amino acid metabolism - nucleotide enzymes

Purine metabolism

Anabolism	R5P->IMP: Ribose-phosphate diphosphokinase - Amidophosphoribosyltransferase - Phosphoribosylglycinamide formyltransferase - AIR synthetase (FGAM cyclase) - Phosphoribosylaminoimidazole carboxylase - Phosphoribosylaminoimidazolesuccinocarboxamide synthase - IMP synthase IMP->AMP: Adenylosuccinate synthase - Adenylosuccinate lyase - reverse (AMP deaminase) IMP->GMP: IMP dehydrogenase - GMP synthase - reverse (GMP reductase)

Nucleotide salvage	Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase

Catabolism	Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase

Pyrimidine metabolism

Anabolism	CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase CTP synthase

Catabolism	Dihydropyrimidine dehydrogenase - Dihydropyrimidinase/DPYS - Beta-ureidopropionase/UPB1

Deoxyribonucleotides

Ribonucleotide reductase - Nucleoside-diphosphate kinase - DCMP deaminase - Thymidylate synthase - Dihydrofolate reductase

see also disorders, intermediates

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