| content | |||||||||||||||||||||||
| Tetradecanoylphorbol acetate | |
|---|---|
 |
|
| IUPAC name | 12-O-tetradecanoylphorbol-13-acetate |
| Other names | TPA, PMA, Phorbol myristate acetate, Tetradecanoylphorbol acetate. |
| Identifiers | |
| CAS number | [16561-29-8] |
| Properties | |
| Molecular formula | C36H56O8 |
| Molar mass | 616.83 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
|
12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as phorbol 12-myristate 13-acetate (PMA), is diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is also being studied as a drug in the treatment of hematologic cancer. TPA is not to be confused with tPA, the former is a small molecule drug, whereas the latter is an enzyme. TPA was first found in the croton plant, a shrub found in Southeast Asia, exposure to which provokes a poison ivy-like rash. It is currently undergoing phase 1 clinical trials.
References
 |
This article does not cite any references or sources. Please help improve this article by adding citations to reliable sources. Unverifiable material may be challenged and removed. (September 2007) |
External links
- MeSH Tetradecanoylphorbol+Acetate
- "NCI Dictionary Entry". Retrieved on 2005-07-02.
- "Phase 1 Clinical Trials". Retrieved on 2005-07-02.
