An extensive section of the Pacific Highway (over 600 miles), from approximately Stockton, California to Vancouver, Washington, followed very closely the track of the Siskiyou Trail. The Siskiyou Trail was based on an ancient network of Native American footpaths connecting the Pacific Northwest with California's Central Valley. By the 1820s, trappers from the Hudson's Bay Company were the first non-Native Americans to use the route of the Pacific Highway to move between today's Washington State and California. During the second half of the 19th Century, mule trains, stagecoaches, and the Central Pacific railroad also followed the route of the Siskiyou Trail.
In the early 20th century, entrepreneur Sam Hill lobbied the governments of Washington and Oregon to build automobileroads along the path of the Siskiyou Trail, with the ultimate goal of building a paved auto route from Canada to Mexico.