Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha, also known as PPARGC1A or PGC-1α, is a human gene.
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptorPPAR-γ, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.[1]
Soyal S, Krempler F, Oberkofler H, Patsch W (2007). "PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes.". Diabetologia49 (7): 1477–88. doi:10.1007/s00125-006-0268-6. PMID 16752166.
