Ōhira expected that the motion would fail, and was visibly shaken when it passed 243-187. Sixty-nine members of his own LDP, including Fukuda, abstained. Given the choice of resigning or calling new elections, Ōhira chose the latter and began campaigning for LDP candidates. He was hospitalized for exhaustion on May 31 and died of a massive heart attack 12 days later. Chief Cabinet Secretary Masayoshi Ito acted in Ōhira's place by deputy after his death. Yoshio Sakurauchi, the Secretary General of LDP, led the LDP to its greatest victory in fifteen years, capitalizing on the sympathy vote generated by Ōhira's death. The Prime Minister was succeeded by Zenko Suzuki after the election.
In 1979, he was the chairman of the 5th G7 summit in Tokyo and its host.