Oddone Frangipane (also Oddo or Otto, Latin: Odo Frajapanis1) was the son of Leo and grandson of Cencio II of the Frangipani family. He had another brother named Cencio. The middle of the twelfth century, he was the most influential aristocrat in Rome. His career began sometime around 1130. He supported the legitimate popes and opposed the Ghibellines and their Senate.
Oddone took over the military leadership of the city of Rome during the absence of Alexander and even afterwards. His son Leo was captured in battle with the emperor's troops in 1167 and he himself led the largest army of Roman citizens since the days of the Roman Empire into battle at Monte Porzio, where he was defeated by Christian I, Archbishop of Mainz.2
In the spring of 1170, Oddone remarried to a woman named Eudoxia, a Byzantine princess. He had a son by her named Emanuele. He died some time not long after.