The second was a Spanish province in the 1500s. It was first colonized by Spaniards in 1569, led by explorer Diego Fernández de Serpa. It comprised what is now eastern Venezuela, western Guyana, and far northern Brazil. In the following centuries, its jurisdiction was reduced to Cumaná and Barcelona, Anzoátegui and was synonymous with the Province of Cumaná. For most of its existence, the Royal Audience of Santo Domingo oversaw its administrative and judicial matters. In the late 18th century, it was incorporated into the newly created Captaincy General of Venezuela.