The cuneate nucleus is part of dorsal column-medial lemniscus system, carrying fine touch and proprioceptive information from the upper body (above T6, excepting the face and ear - the information from the face and ear is carried by the primary sensory trigeminal nucleus) to the thalamus and cerebellum via the medial lemniscus.
Pathology
It may be affected by vitamin E deficiency exhibiting neuroaxonal swelling.