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Nucleotide salvage
A salvage pathway is a pathway in which nucleotides (purine and pyrimidine ) are synthesized from intermediates in the degradative pathway for nucleotides.
Salvage pathways are used to recover bases and nucleosides that are formed during degradation of RNA and DNA . This is important in some organs because some tissues cannot undergo de novo synthesis .
The salvaged bases and nucleosides can then be converted back into nucleotides.
Substrates The salvage pathway requires distinct substrates:
Pyrimidines Thymidine requires a substrate whose enzyme is called thymidine kinase
Purines Lesch-Nyhan syndrome is associated with a deficiency of HGPRT.
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