A spot on North Bentinck Arm is historically significant as the location where Hudson's Bay Company explorer Alexander MacKenzie reached the waters of the Pacific Ocean overland from Rupert's Land. A boulder on the shoreline is marked with "Alexander MacKenzie, from Canada by land, 1792". By only a few weeks MacKenzie missed meeting Captain George Vancouver, who also visited North Bentinck Arm that year.
The inlet is the territory of the Nuxalk Nation, whose main community adjoins the town of Bella Coola, which is at the head of the inlet. The Nuxalk are also known as the Bella Coola people.