Normochromic

Normochromic
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Normochromic is a form of anemia in which the concentration of hemoglobin in the red blood cells is within the standard range.

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v • d • e

Pathology: hematology · myeloid hematologic disease (primarily D50-D77 · 280-289)

RBCs/
hemoglobinopathy

Polycythemia · Macrocytosis

Anemia

Nutritional

Iron deficiency anemia (Plummer-Vinson syndrome) · Megaloblastic anemia (Pernicious anemia)

Hemolytic

Hereditary	enzyme: G6PD Deficiency · Pyruvate kinase deficiency · Triosephosphate isomerase deficiency hemoglobin: Thalassemia · Sickle-cell disease/trait membrane: Hereditary spherocytosis · Hereditary elliptocytosis · Hereditary stomatocytosis

Acquired	Autoimmune (Warm, Cold) · HUS · MAHA · PNH · PCH · Myelophthisic

Aplastic

Acquired PRCA · Diamond-Blackfan anemia · Fanconi anemia · Sideroblastic anemia

Blood tests

MCV (Normocytic, Microcytic, Macrocytic) · MCHC (Normochromic, Hypochromic)

Other

Methemoglobinemia

Coagulation/platelets/
coagulopathy/
bleeding diathesis

Hypercoagulability	primary: Antithrombin III deficiency · Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden · Hyperprothrombinemia acquired: DIC (Congenital afibrinogenemia, Purpura fulminans) · autoimmune (Antiphospholipid)

Other	Essential thrombocytosis

clotting factor: Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II · XIII

platelet function: Bernard-Soulier syndrome · Glanzmann's thrombasthenia · Hermansky-Pudlak syndrome · Gray platelet syndrome · May Hegglin anomaly · Pelger-Huet anomaly

Purpura: Henoch-Schönlein · TP · ITP (Evans syndrome) · TTP

Thrombocytopenia (Heparin-induced thrombocytopenia)

Monocytes/
macrophages

Histiocytosis	WHO-I (Langerhans cell histiocytosis) WHO-II/non-Langerhans-cell (Juvenile xanthogranuloma, Hemophagocytic lymphohistiocytosis) WHO-III/malignant (Acute monocytic leukemia, Malignant histiocytosis, Erdheim-Chester disease)

Other	Chronic granulomatous disease -cytosis: Monocytosis

-penia: Monocytopenia

Granulocytes

+	-cytosis: granulocytosis (Neutrophilia, Eosinophilia, Basophilia)

·	-penia: Granulocytopenia/agranulocytosis (Neutropenia/Kostmann syndrome · Eosinopenia · Basopenia)

See also hematological malignancy and immune disorders

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