Norfloxacin
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content
Norfloxacin
Systematic (IUPAC) name
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-
3-carboxylic acid
Identifiers
CAS number 70458-96-7
ATC code J01MA06 S01AX12
PubChem 4539
DrugBank APRD00469
Chemical data
Formula C16H18FN3O3 
Mol. mass 319.331 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism hepatic
Half life 3 to 4 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes oral

Norfloxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections. It is also sometimes used to treat stomach infections.

Mechanism of action

The mechanism of action of norfloxacin involves inhibition of the A subunit of bacterial DNA gyrase, an enzyme which is essential for DNA replication.1

References

  1. ^ Goldstein E (1987). "Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity". Am J Med 82 (6B): 3–17. doi:10.1016/0002-9343(87)90612-7. PMID 3111257. 
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†Undergoing clinical trials. ‡ Withdrawn from market. § Veterinary use medications.
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