The classic eicosanoids are autocrine and paracrine mediators, active at micromolar concentrations (or lower), produced with high stereospecificity. They are produced from EPAs (chiefly AA) from either cyclooxygenase (COX) or 5-lipoxygenase.
Broadly, the nonclassic eicosanoids are the products of 20-carbon EFAs and 9
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