Noggin (protein)
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Noggin
PDB rendering based on 1m4u.
Available structures: 1m4u
Identifiers
Symbols	NOG; SYM1; SYNS1
External IDs	OMIM: 602991 MGI: 104327 HomoloGene: 3979
Gene ontology Molecular function: • protein binding Cellular component: • extracellular space Biological process: • ureteric bud development • pattern specification process • brain development • sensory perception of sound • cell differentiation • BMP signaling pathway • negative regulation of cell differentiation • cartilage development
Orthologs
	Human	Mouse
Entrez	9241	18121
Ensembl	ENSG00000183691	ENSMUSG00000048616
Uniprot	Q13253	Q5SRD8
Refseq	NM_005450 (mRNA) NP_005441 (protein)	NM_008711 (mRNA) NP_032737 (protein)
Location	Chr 17: 52.03 - 52.03 Mb	Chr 11: 89.12 - 89.12 Mb
Pubmed search	[1]	[2]

Noggin is a polypeptide that inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.

Discovery

Noggin was discovered in the laboratory of Richard M. Harland at the University of California, Berkeley because of its ability to induce secondary axis formation in frog embryos.¹

References

Further reading

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