Neuraminidase inhibitor

Neuraminidase inhibitor
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Neuraminidase_inhibitor".

Neuraminidase inhibitors are a class of antiviral drugs targeted at the influenza viruses whose mode of action consists of blocking the function of the viral neuraminidase protein, thus preventing the virus from budding from the host cell (reproducing).

Oseltamivir, zanamivir and peramivir belong to this class.

Unlike the M2 inhibitors, which work only against the influenza A, neuraminidase inhibitors act against both influenza A and influenza B.

Sources

^ Gubareva LV (2004). "Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors". Virus Research 103: 199–203. doi:10.1016/j.virusres.2004.02.034. DOI

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v • d • e Antivirals, other than for HIV (primarily J05, also S01AD and D06BB)

Anti-herpesvirus (DNA, I)	purine analogue (guanine) (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) · Vidarabine pyrimidine analogue (uridine) (Idoxuridine, Trifluridine) · Brivudine · Cidofovir Docosanol · Fomivirsen · Foscarnet · Tromantadine

HPV/MC (DNA, I)	Imiquimod · Podophyllotoxin

Hepatitis B (DNA, VII)	Adefovir · Clevudine · Interferon alfa-2b · Pegylated interferon alfa-2a · Entecavir · Lamivudine · Telbivudine · Tenofovir

Hepatitis C (RNA, IV)	Pegylated interferon alpha · Ribavirin · Taribavirin^† · Boceprevir^† · Telaprevir^†

Picornavirus (RNA, IV)	Pleconaril^†

Anti-influenza agents (RNA, V)	Arbidol adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir^†)

HIV (Reverse, VI)	See HIV pharm

Other antiviral agents	general (Inosine, Interferon)

^†Undergoing clinical trials, not FDA approved.

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Sources