The Natisone (Latin: Natiso; Friulian: Nadison; Slovenian: Nadiža) is a river of Eastern Friuli, in north-eastern Italy. It is the main tributary of the Torre and a sub-affluent of the Isonzo.
The Natisone is formed at 415 m above sea level on the border between Friuli and Slovenia by the confluence of two streams: the Rio Bianco (Slovenian: Bela Nadiža) and the Rio Nero (Slovenian: Črni Patok) which spring from the Punta di Montemaggiore and Gabrovig mountains. Before the confluence with the Torre, it passes through the communes of Pulfero and Cividale del Friuli.