Depending of the mineral content of the different vapours, mofette may be used for therapeutic purposes as well. As carbon dioxide is heavier than the air, patients can use it as dry spa, if certain safety regulations are complied with. The first known record about mofetta treatment for injuries is from the 16th Century, by Paracelsus.
Today, the balneo-technology of the dry carbon-dioxide gas-bath using frozen carbon-dioxide (dry ice) is also used to reproduce the effects of a natural mofette.