The marriage produced one daughter, the Infanta María Luisa Isabel, who was born on August 21st 1817; she died on January 9 1818 in Madrid; Maria Isabel was again pregnant soon after the birth of her firstborn, but the birth was a difficult one. The baby was in breech and the physicians soon found that the child had died. Maria Isabel stopped breathing soon thereafter and the doctors thought she was dead; when they started cutting her up to extract the dead fetus, she suddenly shouted in pain and collapsed on her bed, bleeding heavily.
She died on 29 November 1818 and was buried at the Escorial, having failed to provide her husband with an heir to the throne.
It is due to Queen Isabel, in which dedication and afection to the art world, that she managed to gather the treasures from the past and create a royal museum, in which would end up by being the beginnings of Museo del Prado, in Madrid. It opened at 19 of November, 1819, a year after the Queen's death.
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