Dordain began his scientific career in the French Space agency (then called ONERA, now CNES) and later worked as a professor at the National Higher School of Aeronautics and Aerospace in the 1970s and 1980s. He has conducted extensive research in rocket engines and microgravity experiments. He was also a European astronaut candidate.
In 1998 he was Executive Secretary at the Japanese Space Agency (then NASDA, now JAXA) and later started as Technical Director at ESA where he became Director General in July 2003.
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