The first section of I-10 in Florida was completed between Sanderson and Jacksonville in 1961. Construction on points westward continued in 1962. The route between Sanderson and Winfield was completed in 1963. By 1967, construction had been completed from the Alabama State Line to SR 87, and under construction from Falmouth to I-75. New construction extending I-10 east from SR 87 to Mossy Head began in 1968. The Falmouth to I-75 segment opened in 1969. Construction began in 1970 further extending I-10 westward from Mossy Head to DeFuniak Springs. New construction began in 1973 from DeFuniak Springs to Caryville and from Drifton to Capitola; the segment between Drifton and Falmouth opened that year. The Capitola to Drifton segment was completed the following year. Construction began between Caryville and Chipley in 1974, and from Chipley to Midway in 1975. The segment between Chipley and Midway was completed in 1977 except for a small portion between Kynesville and Oakdale. In 1978, the entire length of I-10 across the state opened along its original planned route.[2]
On September 16, 2004, Hurricane Ivan made landfall near Pensacola, causing heavy damage to the Interstate 10 bridge across Escambia Bay. As much as a quarter mile (400 m) of the bridge collapsed into the bay. The causeway that carries U.S. Highway 90 across the northern part of the same bay was also heavily damaged. A $26.5 million project was awarded the following day to Gilbert Southern/Massman and to the Parsons Corporation to make emergency repairs to the bridge. Work was completed on October 4 on the westbound bridge, restoring two-way traffic seven days ahead of schedule. The more heavily damaged eastbound bridge was completely repaired on November 20, just 66 days after Hurricane Ivan made landfall. Overall, the project was completed 27 days ahead of schedule.