Interleukin-27 (IL-27) is a heterodimericcytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30).[1] IL-27 is produced by antigen-presenting cells.[2] IL-27 plays an important function in regulating the activity of B and T lymphocytes.[3] The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL-27R and gp130. The gene symbol IL27 refers to the IL-30 subunit of IL-27.[4]
References
^ F. Larousserie et al., Analysis of Interleukin-27 (EBI3/p28) Expression in Epstein-Barr Virus- and Human T-Cell Leukemia Virus Type 1-Associated Lymphomas Heterogeneous Expression of EBI3 Subunit by Tumoral Cells, American Journal of Pathology, 2005, Volume 166, pages 1217-1228.
