IFNA1
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "IFNA1".

content
Interferon, alpha 1
Identifiers
Symbols IFNA1; IFL; IFN; IFN-ALPHA; IFNA13; IFNA@; MGC138207; MGC138505; MGC138507
External IDs OMIM: 147660 HomoloGene: 88748
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3439 n/a
Ensembl ENSG00000197919 n/a
Uniprot P01562 n/a
Refseq NM_024013 (mRNA)
NP_076918 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 9: 21.43 - 21.43 Mb n/a
Pubmed search [1] n/a

Interferon, alpha 1, also known as IFNA1, is a human gene.[1]

Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma; MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes.[supplied by OMIM][1]

References

  1. ^ a b "Entrez Gene: IFNA1 interferon, alpha 1".

Further reading

  • Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis.". Immunobiology 209 (1-2): 99–115. PMID 15481145. 
  • Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega.". Growth Factors 22 (4): 243–51. doi:10.1080/08977190400000833. PMID 15621727. 
  • Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines.". Mini reviews in medicinal chemistry 5 (12): 1093–101. PMID 16375755. 
  • Capobianchi MR, Ankel H, Ameglio F, et al. (1992). "Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer.". AIDS Res. Hum. Retroviruses 8 (5): 575–9. PMID 1381203. 
  • Olopade OI, Bohlander SK, Pomykala H, et al. (1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia.". Genomics 14 (2): 437–43. PMID 1385305. 
  • Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818. 
  • Delcayre AX, Salas F, Mathur S, et al. (1991). "Epstein Barr virus/complement C3d receptor is an interferon alpha receptor.". EMBO J. 10 (4): 919–26. PMID 1849076. 
  • Tyring SK, Cauda R, Tumbarello M, et al. (1991). "Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2.". Viral Immunol. 4 (1): 33–42. PMID 1905933. 
  • Göttlinger HG, Dorfman T, Sodroski JG, Haseltine WA (1991). "Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.". Proc. Natl. Acad. Sci. U.S.A. 88 (8): 3195–9. PMID 2014240. 
  • Stine KC, Bolognesi D, Weinhold KJ (1989). "Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.". Journal of biological response modifiers 8 (5): 501–10. PMID 2552026. 
  • Capon DJ, Shepard HM, Goeddel DV (1985). "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.". Mol. Cell. Biol. 5 (4): 768–79. PMID 2985969. 
  • Delfraissy JF, Wallon C, Galanaud P (1988). "Interferon-alpha can synergize with interleukin 2 for human in vitro antibody response.". Eur. J. Immunol. 18 (9): 1379–84. PMID 3262520. 
  • Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes.". J. Mol. Biol. 185 (2): 227–60. PMID 4057246. 
  • Taniguchi T, Mantei N, Schwarzstein M, et al. (1980). "Human leukocyte and fibroblast interferons are structurally related.". Nature 285 (5766): 547–9. PMID 6157095. 
  • Mantei N, Schwarzstein M, Streuli M, et al. (1980). "The nucleotide sequence of a cloned human leukocyte interferon cDNA.". Gene 10 (1): 1–10. PMID 6157600. 
  • Nagata S, Mantei N, Weissmann C (1981). "The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha.". Nature 287 (5781): 401–8. PMID 6159536. 
  • Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs.". Nature 290 (5801): 20–6. PMID 6163083. 
  • Weber H, Weissmann C (1983). "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli.". Nucleic Acids Res. 11 (16): 5661–9. PMID 6310510. 
  • Todokoro K, Kioussis D, Weissmann C (1984). "Two non-allelic human interferon alpha genes with identical coding regions.". EMBO J. 3 (8): 1809–12. PMID 6479148. 
  • Ameglio F, Capobianchi MR, Castilletti C, et al. (1994). "Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines.". Clin. Exp. Immunol. 95 (3): 455–8. PMID 7511078. 
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