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| Hyperforin | |
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| IUPAC name | (1S,5S,7S,8R)-4-hydroxy-8-methyl-3,5,7 -tris(3-methylbut-2-enyl)-8-(4-methylpent- 3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1] non-3-ene-2,9-dione |
| Identifiers | |
| CAS number | [11079-53-1] |
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| Properties | |
| Molecular formula | C35H52O4 |
| Molar mass | 536.78 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Hyperforin is one of the principal constituents identified in St John's wort. Hyperforin is a prenylated phloroglucinol believed to be the main active constituent responsible for its antidepressant effects.[1] Hyperforin has been shown to inhibit the uptake of 5-HT(serotonin), dopamine, noradrenaline, GABA and glutamate.[2] Hyperforin is also thought to be responsible for the induction of the cytochrome P450 enzymes CYP3A4 and CYP2C9 by binding to the Pregnane X Receptor (PXR).
As ejaculatory control
Hyperforin and other serotonin agonists significantly reduces the pelvic floor contractions elicited by 8-OH-DPAT.[3] Thus, pharmacological modulation of the ejaculatory threshold using serotonin reuptake inhibitors and hyperforin may offer patients an option of achieving improved ejaculatory control.
See also
References
- ^ Newall, Carol A.; Joanne Barnes; Anderson, Linda R. (2002). Herbal medicines: a guide for healthcare professionals. London: Pharmaceutical Press. ISBN 0-85369-474-5.
- ^ Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE (1998). "Hyperforin as a possible antidepressant component of hypericum extracts". Life Sci. 63 (6): 499–510. doi:. PMID 9718074.
- ^ Thomas CA, Tyagi S, Yoshimura N, Chancellor MB, Tyagi P (2007). "Effect of hyperforin-enriched extract on pro-ejaculatory effect of 8-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats". Urology 70 (4): 813–6. doi:. PMID 17991578.
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