Hexosaminidase
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Hexosaminidase".

content
Identifiers
Symbol HEXA
Entrez 3073
HUGO 4878
OMIM 606869
RefSeq NM_000520
UniProt P06865
Other data
EC number 3.2.1.52
Locus Chr. 15 q24.1
Identifiers
Symbol HEXB
Entrez 3074
HUGO 4879
OMIM 606873
RefSeq NM_000521
UniProt P07686
Other data
EC number 3.2.1.52
Locus Chr. 5 q13.3
hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Identifiers
Symbol HEXDC
Entrez 284004
HUGO 26307
RefSeq NM_173620
UniProt Q8IYN4
Other data
Locus Chr. 17 q25.3

Hexosaminidase is an autolysin enzyme involved in the hydrolysis of several molecules containing hexose.

Pathology

Deficiencies cause an inability to properly hydrolyze certain sphingolipids, causing these lipids to accumulate over time in lysosomes. Disorders of Hexosaminidase are responsible for the following conditions:

ex. Muramidase - Cleaves β-1,4 linkages between N-Acetylmuramic Acid (NAM) and N-Acetylglutamine (NAG).

External links

 This hydrolase article is a stub. You can help Wikipedia by expanding it.
v • d • e
Hydrolase: sugar hydrolases (EC 3.2)
3.2.1: Glycoside hydrolases
3.2.2: Hydrolysing N-Glycosyl compounds
v • d • e
Metabolism: lipid metabolism - glycolipid/sphingolipid enzymes
To glycosphingolipid
To ceramide
To sphingosine
Other
v • d • e
Metabolism: carbohydrate metabolism - glycoprotein enzymes
Anabolism
Catabolism
Transport
M6P tagging
see also disorders
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