Glycerol-3-phosphate dehydrogenase
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Glycerol-3-phosphate_dehydrogenase".

glycerol-3-phosphate dehydrogenase 1 (soluble)
Identifiers
Symbol	GPD1
Entrez	2819
HUGO	4455
OMIM	138420
RefSeq	NM_005276
UniProt	P21695
Other data
EC number	1.1.1.8
Locus	Chr. 12 q12-q13

Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate (aka glycerone phosphate, outdated).

Older terms for glycerol-3-phosphate dehydrogenase include alpha glycerol-3-phosphate dehydrogenase (alphaGPDH) and glycerolphosphate dehydrogenase (GPDH). However, glycerol-3-phosphate dehydrogenase is not the same as glyceraldehyde 3-phosphate dehydrogenase (GAPDH) whose substrate is an aldehyde not an alcohol.

Reaction

The reaction catalyzed by cytosolic GPDH is as follows:

Glycerol-3-phosphate shuttle

Main article: Glycerol phosphate shuttle

The cytosolic together with the mitochondrial glycerol-3-phosphate dehydrogenase work in concert. Oxidation of cytoplasmic NADH by the cytosolic form of the enzyme creates glycerol-3-phosphate from dihydroxyacetone phosphate. Once the Glycerol-3-phosphate has moved through the Outer Mitochondrial Membrane it can then be oxidised by a separate isoform of glycerol-3-phosphate dehydrogenase. This differ as it is instead FADH2 linked. As a result there is a net loss in energy, comparable to 1 ATP. Illustrated here [1].

See also

• substrate pages: glycerol 3-phosphate, dihydroxyacetone phosphate
• related topics: glycerol phosphate shuttle, creatine kinase, glycolysis, gluconeogenesis

External links

• equivalent entries: MeSH alphaGPDH and GPDH

References

• IUBMB entry for 1.1.1.8
• BRENDA references for 1.1.1.8 (Recommended.)
• PubMed references for 1.1.1.8
• PubMed Central references for 1.1.1.8
• Google Scholar references for 1.1.1.8

External links

• Yeast genome database GO term: GPDH
• enzyme no. -2053504966 at GPnotebook

• IUBMB entry for 1.1.1.8

• KEGG entry for 1.1.1.8

• BRENDA entry for 1.1.1.8

• NiceZyme view of 1.1.1.8

• EC2PDB: PDB structures for 1.1.1.8

• PRIAM entry for 1.1.1.8

• PUMA2 entry for 1.1.1.8

• IntEnz: Integrated Enzyme entry for 1.1.1.8

• MetaCyc entry for 1.1.1.8

• Atomic-resolution structures of enzymes belonging to this class

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