Giovanni Domenico Santorini (June 6, 1681 - May 7, 1737) was an Italian anatomist who received his medical doctorate from Pisa in 1701. He is remembered for his anatomical dissections of the human body.
From 1705 until 1728, Santorini performed anatomical demonstrations in Venice. His best written work was the 1724 publication of Observationes anatomicae, which is a detailed work concerning anatomical aspects of the human body. He is credited for being the first to describe several anatomical structures, including the following:
Santorini's muscle: Bundle of muscular fibers that draw the angle of the mouth laterally. Also sometimes called the Albinus muscle; named after German anatomist Bernhard Siegfried Albinus (1697-1770).