Gattermann-Koch reaction
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The Gattermann-Koch reaction, named for the German chemists Ludwig Gattermann and Julius Arnold Koch,¹ in organic chemistry refers to a Friedel-Crafts acylation reaction in which carbon monoxide and hydrochloric acid are used in-situ with Friedel-Crafts catalyst, namely AlCl₃ to produce a benzaldehyde-derivative from a benzene-derivative in one step.² Benzaldehyde and many aromatic aldehydes are conveniently synthesized by this reaction. Presence of traces of copper(I) chloride are also needed.

An example would be the conversion of toluene to p-tolualdehyde.³

See also

• Friedel-Crafts reaction
• Gattermann reaction

References

1. ^ Gattermann, L.; Koch, J. A. (1897). "Eine Synthese aromatischer Aldehyde". Ber. 30: 1622. doi:10.1002/cber.18970300288. 
2. ^ LI Jie Jack (2003). Name Reactions: A Collection of Detailed Reaction Mechanisms (available on Google Books), 2nd edition, Springer, 157. ISBN 3540402039. 
3. ^ G. H. Coleman, David Craig (1943). "p-Tolualdehyde". Org. Synth.; Coll. Vol. 2: 583. 

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