G-protein coupled receptor kinases
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "G-protein_coupled_receptor_kinases".

G-Protein coupled receptor kinases (GRKs), regulate the activity of G-protein coupled receptors by phosphorylating their intracellular domains after their associated G-proteins have been released and activated.

The phosphorylated serines and threonine residues act as binding sites for arrestin proteins which prevent the reassociation of the G-proteins with their receptors, thereby preventing reactivation of the signaling pathway.

Types

content
Name Notes OMIM Gene
G-protein coupled receptor kinase 1 rhodopsin kinase 180381 GRK1
G-protein coupled receptor kinase 2 (BARK1) β-adrenergic receptor kinase 1 109635 ADRBK1
G-protein coupled receptor kinase 3 (BARK2) β-adrenergic receptor kinase-2 109636 ADRBK2
G-protein coupled receptor kinase 4 has been associated with regulation of kidney tubule function 137026 GRK4
G-protein coupled receptor kinase 5 Transgenic mice lacking #5 have altered core body temperature 600870 GRK5
G-protein coupled receptor kinase 6 Transgenic mice lacking #6 have altered response to leukotriene B4 600869 GRK6
G-protein coupled receptor kinase 7 cone opsin kinase GRK7

External links


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v • d • e
Kinases: Serine/threonine-specific protein kinases (primarily EC 2.7.11)
2.7.11
2.7.12
MAP2K (1, 2, 3, 4, 5, 6, 7)
2.7.1.37, or unknown
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