Drypteis was given in marriage by her grandmother to Hephaestion Amyntoros at the Susa wedding where her sister married Alexander in 324 BC.
Although not mentioned by name, she was most likely captured by Alexander at the Battle of Issus in 333 BCE along with the rest of the Persian royal family of Darius III.
She also was widowed in 324 BCE. Following the death of Alexander in 323 BCE, Drypteis and her sister Stateira II - Alexander's widow - were murdered by Alexander's other widow, Roxana (Pl. Alex. 77.4).